ultrasound assisted curcumin extraction machine

Ultrasonic dynamic curcumin extraction concentration equipment

The main sources of curcumin are the rhizomes of Curcuma aromatica Salisb., C. longa L., C. zedoaria (Berg.) Rosc., and Acorus calamus L. in the Araceae family.  

Curcumin is an orange yellow crystalline powder with a slightly bitter taste. It is insoluble in water and ethylene glycol, soluble in ethanol and propylene glycol, and easily soluble in glacial acetic acid and alkaline solutions. It appears reddish brown in alkaline conditions and yellow in neutral and acidic conditions. Measure according to the OT-42 method. Melting range 179-182 ℃.
Curcumin has strong stability towards reducing agents and strong coloring properties. Once colored, it is not easy to fade, but it is sensitive to light, heat, and iron ions, and has poor resistance to light, heat, and iron ions.

Due to the presence of two hydroxyl groups at both ends of curcumin molecules, the conjugation effect of electron cloud deviation occurs under alkaline conditions. Therefore, when the pH is greater than 8, curcumin will turn from yellow to red. Modern chemistry utilizes this property as an acid-base indicator.

Experiment on extraction concentration of herbals medicine powder for reference: https://youtube.com/shorts/c4zLXaO6pas 

With the continuous development of ultrasonic technology and the expansion of application fields, the ultrasonic extraction machine market presents a good development prospect. It is predicted that the market size of ultrasonic extraction equipment will grow steadily in the next few years, with food, pharmaceuticals, cosmetics and other fields being the main growth points. Meanwhile, with the increasing awareness of environmental protection, the application of ultrasonic extraction machines in the field of environmental protection will gradually expand.
In short, ultrasonic extraction machines, with their unique principles and technological advantages, have brought tremendous changes to industries such as modern chemical, pharmaceutical, food, and environmental protection. With the continuous growth of market demand and technological innovation, ultrasonic extraction machines will play a more important role in the future.

Structure of ultrasound assisted curcumin extraction machine

1.This device has the advantages of small footprint, exquisite production, complete supporting facilities, and easy operation. Especially suitable for small-scale and multi variety production methods.  
2. This equipment is equipped with supporting accessories such as vacuum pump, liquid pump, filter, liquid receiving tank, control cabinet, etc. The equipment is divided into steam heating and electric heating. After purchasing, the equipment only needs to be connected to water, electricity or steam to be used.  
3. The equipment is fully functional, suitable for water extraction and alcohol extraction, capable of atmospheric and negative pressure extraction, and can recover volatile oils. Configure a vacuum converter and control box, easy to operate, capable of achieving extraction and concentration at room temperature and low temperature; Extraction and concentration at room temperature; Process requirements for low-temperature extraction and concentration.  
4. Electric heating structure design, high efficiency, safety, fast heating and cooling, and uniform heating. The tank is equipped with a safety pressure relief device to ensure safe use.  
5. It can achieve reflux extraction process, reduce extraction and concentration time, and save solvents.
6. The oil-water separator design integrates vacuum conversion function to achieve better oil-water separation effect. Made of glass material for easy observation.

Ultrasonic assisted curcumin extraction machine: panoramic analysis of core information
Curcumin is the core active ingredient of turmeric, which has a wide range of pharmacological activities such as anti-inflammatory, antioxidant, and anti-tumor. However, it has the characteristics of strong heat sensitivity (easily decomposed above 60 ℃), tight cell wall encapsulation, and poor lipid solubility. Ultrasonic assisted extraction technology has become the mainstream process for curcumin extraction through high-frequency vibration for wall breaking and low-temperature efficient dissolution. The following are the four core information:
Working principle: High frequency vibration+cavitation effect, low-temperature and efficient wall breaking dissolution
The core of the ultrasonic assisted extraction machine is to achieve efficient extraction of curcumin through ultrasonic cavitation effect. The specific process is as follows:
Ultrasonic Generation and Conversion: The ultrasonic signal generator inside the equipment generates high-frequency oscillation signals of 20-40kHz, which are converted into high-frequency mechanical oscillations by a transducer (piezoelectric ceramic plate) and transmitted into the solvent turmeric mixture in the extraction tank.
Cavitation effect breaking wall: High frequency oscillation generates a large number of tiny bubbles (cavitation bubbles) in the liquid. When the bubbles quickly close in the positive pressure zone, they release instantaneous high pressure and microjet of thousands of atmospheres, physically breaking the hard cell wall of turmeric (with a breakage rate of over 95%), allowing the turmeric encapsulated inside to be quickly released into the solvent.
Low temperature and efficient dissolution: By circulating stirring and temperature control system, the extraction temperature is controlled at 40-60 ℃ (much lower than the decomposition temperature of curcumin at 60 ℃) to avoid thermal decomposition of components. At the same time, the fat solubility of solvents (ethanol, methanol, etc.) is utilized to quickly dissolve the released curcumin, achieving efficient extraction.

Ultrasonic dynamic curcumin extraction machine is very suitable for extracting effective ingredients from various natural products using volatile or non-volatile solvents. It is suitable for laboratory and production use in traditional Chinese medicine, food, health products, cosmetics, etc. It can also be used for ultrasonic dispersion, emulsification, release of slow-release drug ultrafine capsules and nanocapsules preparation research. It is an ideal equipment for schools, research institutions, and pharmaceutical enterprises

technical characteristics of Ultrasonic assisted curcumin extraction machine
Curcumin is the core active ingredient of traditional Chinese medicine such as turmeric and turmeric, which has a wide range of pharmacological activities such as anti-inflammatory, antioxidant, and anti-tumor. However, it has the characteristics of strong heat sensitivity (easily decomposed above 60 ℃), tight cell wall encapsulation, and poor lipid solubility. Ultrasonic assisted extraction technology has become the mainstream process for curcumin extraction through high-frequency vibration wall breaking and low-temperature efficient dissolution. The following is the core information of the equipment:
1、 Technical features of the equipment (adapted to the characteristics of curcumin)
Low temperature and efficient wall breaking
Using 20-40kHz high-frequency ultrasound, micro jets and shock waves are generated through cavitation effect to physically break the turmeric cell wall (with a breaking rate of over 95%), while controlling the extraction temperature at 40-60 ℃ to avoid thermal decomposition of curcumin (with a retention rate of over 90%, compared to traditional high-temperature methods which only have 65%).
Accurate parameter adaptation
Based on the lipid solubility characteristics of curcumin, it supports custom settings for solvent types (methanol, ethanol, water ethanol mixture) and concentrations (75% -95%), combined with precise control of solid-liquid ratio (1:10-1:20) and extraction time (20-60 minutes), to achieve maximum extraction efficiency.
Integrated post-processing
Our high-end BIOLAND INSTRUMENT models integrate the "extraction+concentration+nano dispersion" function, which can directly disperse curcumin into nanoparticles below 100nm after extraction, improving water solubility and bioavailability without the need for additional homogenization equipment.
Industrial grade durable design
The core transducer adopts industrial grade piezoelectric ceramic plates, supporting 24-hour continuous operation; The tank body and tool head are made of 316L stainless steel, which is corrosion-resistant, easy to clean, and meets GMP production requirements

Core Process Flow (Industrial Production Version)
Raw material pretreatment
Turmeric rhizome cleaning → drying (below 50 ℃ to avoid component loss) → crushing (particle size 0.5-2mm, increase contact area) → weighing according to the formula.
Solvent configuration and feeding
Prepare a 75% -95% ethanol solution (solid-liquid ratio 1:15), heat it to 45-55 ℃, add turmeric powder into the extraction tank, and start ultrasonic extraction.
Ultrasonic extraction (core step)
Parameter setting: frequency 28-35kHz, power 30-80kW (adjusted according to turmeric hardness), time 40-60 minutes;
Process control: Adopting the "intermittent ultrasound+cyclic stirring" mode (ultrasound for 10 minutes → stirring for 5 minutes) to avoid local overheating and monitor temperature in real-time (error ± 1 ℃).
Solid liquid separation and concentration
After extraction, use plate and frame filtration or centrifugation to separate the drug residue and collect the extraction solution; Curcumin concentrate was obtained by vacuum low-temperature concentration (below 60 ℃), removing the solvent.
Refining and Finished Products
Through macroporous resin adsorption, crystallization and drying (spray drying or freeze drying), curcumin powder or nano lotion with purity ≥ 95% can be obtained, which can be directly used in the production of drugs, health products or cosmetics.

core advantages 
Extraction efficiency: Extraction time reduced to 40-60 minutes, efficiency increased by 50% -500%, single batch production capacity increased by 3-5 times
Ingredient yield: The yield of curcumin has increased by 50% -200% (from 70% in traditional processes to over 95%), and the utilization rate of rare turmeric raw materials has increased from 60% to 90%+
Ingredient activity: Low temperature extraction (40-60 ℃), curcumin retention rate over 90%, impurity content reduced by 40%
Reduce solvent usage by 50% in production costs, energy consumption by 30%, and single batch production costs by 35% -50%
The added value of the product can produce nano-sized curcumin (with a 3-fold increase in water solubility), which is priced 50% -100% higher than ordinary curcumin
Application areas: covering the three core tracks of medicine, health, and beauty
The ultrasound assisted curcumin extraction machine is widely used in the following fields due to its high efficiency, low temperature, and high purity:
pharmaceutical field
Antitumor drugs: Curcumin nano lotion can enhance the targeting of chemotherapy drugs (such as cisplatin), reduce side effects, and is used for adjuvant treatment of liver cancer, colon cancer and other tumors;
Anti inflammatory and analgesic drugs: high-purity curcumin extract is used to develop oral or topical patches for chronic inflammation such as arthritis and rheumatoid arthritis;
Neuroprotective drug: Curcumin can inhibit the deposition of β - amyloid protein and is used for the prevention and treatment of Alzheimer's disease.
Healthy Food and Health Products
Functional food: Curcumin is added to yogurt, capsules, and meal replacement powders, with the main selling points of "anti-inflammatory, antioxidant, and lipid-lowering" to meet the needs of sub-health populations;
Sports nutrition: Curcumin nano lotion is added to sports tonic to relieve muscle soreness and accelerate sports recovery;
Elderly nutrition supplement: High purity curcumin is used to develop elderly nutrition supplements that protect the liver and brain, enhancing immunity.
Cosmetics and Personal Care
Anti aging skin care products: curcumin nano lotion is added to essence liquid and face cream to inhibit melanin production, fade spots, and focus on "anti-oxidation, brighten skin";
Anti inflammatory and soothing products: Curcumin is added to facial mask and toner to alleviate redness and acne inflammation of sensitive muscles, suitable for people with oil acne and sensitive muscles;
Hair care products: Curcumin is added to shampoo and hair masks to repair damaged hair and inhibit dandruff, with the main selling point of "nourishing hair and preventing hair loss".
Agriculture and Feed
Plant pesticides: Curcumin extract can inhibit the growth of pathogenic bacteria and is used to develop natural plant pesticides as an alternative to chemical pesticides;
Animal feed additive: Curcumin is added to feed to enhance the immunity of livestock and poultry, improve meat quality, and reduce the use of antibiotics.

If you want to follow specific cases of ultrasound assisted curcumin extraction machine in pharmaceutical research and development or cosmetic applications, please feel free to contact us by email info@bioland-china.com