1、 Core positioning and applicable scenarios
Positioning: Pilot scale (feeding rate of 5-100 kg/batch, processing capacity of 20-200 L/h), balancing flexibility and engineering validation, connecting laboratory small-scale testing with large-scale production.
Applicable to: R&D and small batch production of extraction, separation and purification process of Chinese herbal pieces, plant extracts, Chinese herbal formula granules, health products, natural essence and flavor, biological fermentation liquid, etc.

Advantages: The entire process is sealed, hygienic, and traceable, supporting various processes such as water extraction, alcohol extraction, hot reflux, low-temperature extraction, membrane separation, etc., with high yield of active ingredients and thorough removal of impurities.

2、 Whole process technology and equipment composition
1. Pre treatment section
Function: Clean, cut, crush, weigh medicinal herbs, remove sediment and impurities, ensure the uniformity of raw materials, and lay the foundation for efficient extraction.
Core equipment: cleaning machine, cutting machine, crusher, weighing tank.
2. Extraction section
Function: Fully dissolve the active ingredients (alkaloids, flavonoids, polysaccharides, volatile oils, etc.) in medicinal materials to achieve preliminary solid-liquid separation.
Core equipment: multifunctional extraction tank (atmospheric/depressurization/pressurization), hot reflux extraction tank, ultrasonic extraction tank, volatile oil extractor; Support water extraction, alcohol extraction, and hot reflux cyclic extraction.
Key parameters: extraction temperature 40-100 ℃, extraction time 1-3 h/time, extraction frequency 2-3 times, solid-liquid ratio 1:8-1:12.
3. Separation and crude purification stage
Function: Remove large particle impurities such as drug residues, fibers, colloids, etc., obtain clear extraction solution, and reduce subsequent concentration load.
Core equipment: Tripod centrifuge, tube/disc separator, plate and frame filter, 200-400 mesh bag filter.
4. Precision purification section (core)
Function: Graded removal of impurities, enrichment of active ingredients, and improvement of extract purity and quality consistency.
Core processes and equipment:
Membrane separation: Ultrafiltration (UF, molecular weight cut-off of 100 kDa -0.18 μ m) removes large molecular impurities; Nanofiltration (NF, 200-1000 Da) concentration and desalination to retain small molecule active ingredients.
Chromatography purification: ion exchange column, silica gel column, macroporous adsorption resin, targeted separation of alkaloids, flavonoids, saponins, etc.
Water sedimentation/alcohol sedimentation: removes impurities such as starch, protein, and tannins, and improves the purity of the extract.
5. Concentration section
Function: Low temperature solvent removal, volume reduction, preparation of high concentration paste, protection of thermosensitive components.
Core equipment: vacuum pressure reducing concentration tank, dual/multi effect concentrator, thin film concentrator; Concentrate at a temperature of 50-70 ℃, vacuum degree of -0.05~-0.08 MPa, and concentrate to a relative density of 1.10-1.35 (measured at 50-60 ℃).
Advantages: Energy saving and efficient, short concentration time, good retention of paste color and effective ingredients.
6. Drying and post-processing section
Function: Make concentrated extract into dry powder, granules or paste for easy storage, transportation and formulation molding.
Core equipment: centrifugal spray dryer, vacuum freeze dryer, hot air circulation oven, granulator.
7. Auxiliary and Control Systems
Auxiliary: CIP in-situ cleaning system, SIP online * * system, solvent recovery system, cooling water circulation system.
Control: PLC touch screen automatic control, real-time parameter display, curve recording, data tracing, supports multi formula storage and one click start stop.

3、 Core technical features
Flexible process: It can switch between water extraction/alcohol extraction, hot reflux, ultrasound, membrane separation, chromatography and other processes to adapt to the characteristics of different medicinal materials and active ingredients.
Low temperature protection: vacuum concentration, low-temperature extraction, reducing the loss of heat sensitive components (such as volatile oils and saponins), ensuring the activity of the extract.
Efficient separation: membrane separation+chromatographic fractionation purification, high impurity removal rate, significantly improved purity and yield of active ingredients.
Sealed hygiene: The entire process is made of 304/316L stainless steel material, seamless welding, no dead corners, and meets GMP hygiene requirements.
High degree of automation: automatic temperature control, pressure control, and time control, reducing human error, and good process reproducibility.
Energy saving and environmental protection: solvent recovery, waste heat utilization, reducing energy consumption and emissions; CIP/SIP simplifies the cleaning process.
4、 Typical application cases
Traditional Chinese medicine formula granules: water extraction of astragalus, angelica, honeysuckle, etc. → membrane separation and purification → vacuum concentration → spray drying and pulverization.
Plant extracts: Extraction, separation, and purification of flavonoids, alkaloids, and polysaccharides to meet high purity requirements.
Health care products/cosmetics: natural plant essence is extracted, concentrated and purified to prepare active stock solution or dry powder.
Biological fermentation broth: Separation, desalination, concentration, and enrichment of active ingredients in fermentation broth.

5、 Key points for selection and customization
Feeding scale: 5-50 kg (small), 50-100 kg (medium), customized according to demand.
Process requirements: Whether volatile oil recovery, membrane separation, chromatography, aseptic operation, etc. are needed.
Material and certification: 316L contact material, GMP certification, sanitary grade fittings and valves.
Automation: manual/semi-automatic/fully automatic control, data traceability and printing output.
Supporting equipment: It can be linked with homogenizers, filling machines, and packaging machines to achieve full process automation production.
6、 Product Value
Provide data support for R&D in optimizing process parameters, establishing quality standards, and verifying stability.
To provide production with: small-scale trial production, process amplification verification, risk pre control, and reduce industrialization costs and risks.